Position paper: Rapid responses to steroids: current status and future...
Steroids exert their actions through several pathways. The classical genomic pathway, which involves binding of steroids to receptors and subsequent modulation of gene expression, is well...
View ArticleGenomic priming of the antisecretory response to estrogen in rat distal colon...
The secretion of Cl(-) across distal colonic crypt cells provides the driving force for the movement of fluid into the luminal space. 17beta-Estradiol (E2) produces a rapid and sustained reduction in...
View ArticleMalignant pleural mesothelioma incidence and survival in the Republic of...
OBJECTIVE: Malignant pleural mesothelioma (MPM) is a rare malignancy associated with exposure to asbestos. The protracted latent period of MPM means that its incidence has continued to rise across...
View ArticlePhysiological levels of lipoxin A4 inhibit ENaC and restore airway surface...
In cystic fibrosis (CF), the airway surface liquid (ASL) is depleted. We previously demonstrated that lipoxin A4 (LXA4) can modulate ASL height (ASLh) through actions on Cl(-) transport. Here, we...
View ArticleEstrogen increases ENaC activity via PKCδ signaling in renal cortical...
The most active estrogen, 17β-estradiol (E2), has previously been shown to stimulate a female sex-specific antisecretory response in the intestine. This effect is thought to contribute to the increase...
View ArticleThe effect of high [K(+)]o on spontaneous Ca(2+) waves in freshly isolated...
Interstitial cells of Cajal (ICC) act as putative pacemaker cells in the rabbit urethra. Pacemaker activity in ICC results from spontaneous global Ca(2+) waves that can be increased in frequency by...
View ArticleA preclinical evaluation of the PI3K alpha/delta dominant inhibitor BAY...
The PI3K pathway is a key mechanism of trastuzumab resistance, but early attempts to indirectly target this pathway with mTOR inhibitors have had limited success. We present the results of a...
View ArticleHER2-family signalling mechanisms, clinical implications and targeting in...
Approximately 20 % of human breast cancers (BC) overexpress HER2 protein, and HER2-positivity is associated with a worse prognosis. Although HER2-targeted therapies have significantly improved...
View ArticleFuroates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically...
The last decade has witnessed the reawakening of cancer metabolism as a therapeutic target. In particular, inhibition of pyruvate dehydrogenase kinase (PDK) holds remarkable promise. Dichloroacetic...
View ArticleCharacterization of AQPs in Mouse, Rat, and Human Colon and Their Selective...
In normal individuals, the epithelium of the colon absorbs 1.5-2 l of water a day to generate dehydrated feces. However, in the condition of bile acid malabsorption (BAM), an excess of bile acids in...
View ArticleRenin-Angiotensin-Aldosterone System Antagonism and Polycystic Kidney Disease...
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a systemic disease characterised by the formation of multiple renal cysts that adversely affect renal function. ADPKD shows significant...
View ArticleTamoxifen Suppresses the Growth of Malignant Pleural Mesothelioma Cells.
INTRODUCTION: Malignant pleural mesothelioma (MPM) is a rare but highly aggressive malignancy most often associated with exposure to asbestos. Recent evidence points to oestrogen receptor (ER)-β...
View ArticleBidirectional KCNQ1:β-catenin interaction drives colorectal cancer cell...
The K+ channel KCNQ1 has been proposed as a tumor suppressor in colorectal cancer (CRC). We investigated the molecular mechanisms regulating KCNQ1:β-catenin bidirectional interactions and their...
View ArticleImpact of somatic PI3K pathway and ERBB family mutations on pathological...
BACKGROUND: The Cancer Genome Atlas analysis revealed that somatic EGFR, receptor tyrosine-protein kinase erbB-2 (ERBB2), Erb-B2 receptor tyrosine kinase 3 (ERBB3) and Erb-B2 receptor tyrosine kinase...
View ArticlePreclinical evaluation and reverse phase protein Array-based profiling of...
BACKGROUND: The phosphoinositide-3-kinase (PI3K) pathway is the most commonly activated pathway in cancers due to mutations at multiple nodes and loss of PTEN. Furthermore, in endometrial cancer (EC),...
View ArticleUrsodeoxycholic acid attenuates colonic epithelial secretory function.
Dihydroxy bile acids, such as chenodeoxycholic acid (CDCA), are well known to promote colonic fluid and electrolyte secretion, thereby causing diarrhoea associated with bile acid malabsorption....
View ArticleFarnesoid X receptor agonists attenuate colonic epithelial secretory function...
OBJECTIVE: Bile acids are important regulators of intestinal physiology, and the nuclear bile acid receptor, farnesoid X receptor (FXR), is emerging as a promising therapeutic target for several...
View ArticleUrsodeoxycholic acid inhibits TNFα-induced IL-8 release from monocytes.
Monocytes are critical to the pathogenesis of inflammatory bowel disease (IBD) as they infiltrate the mucosa and release cytokines that drive the inflammatory response. Ursodeoxycholic acid (UDCA), a...
View ArticleThe bile acid receptor, TGR5, regulates basal and cholinergic-induced...
Bile acids (BA) are becoming increasingly appreciated as enteric hormones that regulate many aspects of intestinal physiology. The BA receptor, TGR5, has been recently shown to be expressed on enteric...
View ArticleMarkers of MEK inhibitor resistance in low-grade serous ovarian cancer: EGFR...
Background: Although low-grade serous ovarian cancer (LGSC) is rare, case-fatality rates are high as most patients present with advanced disease and current cytotoxic therapies are not overly...
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